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New research: A molecular ‘warhead’ against disease

New research: A molecular ‘warhead’ against disease

April 4, 2024

In the battle against cancer and other diseases, scientists are developing molecular weapons that can be used to stop uncontrollable cell growth.

A team of Harvard and Massachusetts General Hospital scientists have found that “cyclimids,” a class of binding molecules known as ligands, offer a promising and efficient approach to removing disease-causing or malfunctioning proteins. Their distinct properties enable scientists to attack errant proteins at their molecular roots.

“For over a year we had been...

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New research: Messenger RNAs with multiple “tails” could lead to more effective therapeutics

New research: Messenger RNAs with multiple “tails” could lead to more effective therapeutics

April 3, 2024

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed as a new class of drugs. For mRNAs to have broad therapeutic uses, however, the molecules will need to last longer in the body than those that make up the COVID vaccines. 

Researchers from the Broad Institute of MIT and Harvard and MIT have engineered a new mRNA structure by adding multiple “tails” to the molecules that...

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