Professor Bin Zhang, MIT.  "Genome Organization through Phase Separation: Random yet Precise."  Woodward CCB Departmental Colloquium.

Abstract: The three-dimensional genome organization plays an essential role in all DNA-templated processes, including gene transcription, gene regulation, DNA replication, etc. Coarse-grained models parameterized to reproduce experimental data via the maximum entropy optimization algorithm serve as effective means to study genome organization at various length scales. They have provided insight into the principles of whole-genome organization and enabled de novo predictions of chromosome structures from epigenetic modifications. In addition, they provided insight into the critical role of the chromatin network in stabilizing multiple liquid droplets. Applications of these models at a near-atomic resolution further revealed physicochemical interactions that drive the phase separation of disordered proteins and dictate chromatin stability in situ.

 

Hi there,

You are invited to a Zoom webinar.
When: Mar 10, 2022 04:00 PM Eastern Time (US and Canada)
   
  

Please click the link below to join the webinar:
https://harvard.zoom.us/j/92317148315?pwd=K0JnS2N6ZjJwY0JsTFFDaFJ5bmpudz09
Passcode: 944632
Or One tap mobile : 
    US: +13126266799,,92317148315#  or +19294362866,,92317148315#