Merck-Banyu Lecture - Dr. Kohsuke Ohmatsu & Dr. Koji Hirano

Date: 

Friday, October 21, 2022, 2:00pm to 3:00pm

Location: 

Pfizer Lecture Hall

Dr. Kohsuke Ohmatsu

Associate Professor, Institute of Transformative Bio-Molecules,

Nagoya University

Exploiting Ionic Molecules for Hitherto Difficult Catalytic Transformation.

Dr.Ohmatsu has developed novel ionic ligands and ionic organ catalysts:

1)ion-pairedligandconsistingofcationicachiralphosphineandchiralanion; 2)chiral onium−phosphine hybrid ligand and; 3)chiral1,2,3-triazoliumionhavingstronganion-bindingability.

These catalysts enabled challenging asymmetric transformations such as construction of contiguous all-carbon quaternary stereocenters. He also developed a unique ionic radical catalyst: 4)zwitterionic triazolium amidate that allowed for efficient C(sp3)−H alkylation of various organic compounds.

 

 

Dr. Koji Hirano

Associate Professor, Department of Applied Chemistry, Graduate School of Engineering, Osaka University

Development of New Bond Forming Strategies by Extended Umpolung

Dr.Hirano has extended the concept of traditional carbonyl umpolung to aromatic compounds as well as heteroatom species and developed new C–C and C–heteroatom bond forming strategies: 1)direct aromatic couplings via Cu-mediated C–H activation; 2)highly regio-and enantioselective aminoboration and hydroamination of alkenes via Cu-mediated electrophilic amination; 3)C–C/C–Pbond forming sequence and rapid construction of phospholes via Tf2O-mediated electrophilic phosphination. These studies enable the otherwise challenging molecular transformation sand greatly contribute to the development of organic synthetic chemistry.