The microorganisms living in, on, and around us, collectively known as the microbiome, produce metabolites that affect our health. Some of these molecules are essential for our wellbeing, while others can harm us. Colibactin is an example of a toxin, produced as part of microbial warfare, which induces double-stranded breaks in the DNA of cells in the intestinal epithelium and is correlated with higher incidences of diseases such as colorectal cancer.
Bacteria producing colibactin must protect their own DNA, so they assemble a non-toxic precursor (precolibactin) in their...
Read more about How E. coli bacteria activate a toxin they produce in a way that avoids self-harm