CCB's long and illustrious history of accomplishment in the area of carbon-containing compounds is exemplified by pioneering syntheses of the complex molecules palytoxin and vitamin B12. With emphasis on development of new reaction methodology and synthesis of families of molecules ranging from small probes to large compounds with antimicrobial and antibiotic activity, and creation of supramolecular assemblies of relevance to energy conversion, Harvard’s organic chemistry effort continues to be multifaceted and fruitful.