At MIT Professor Stubbe studies ribonucleotide reductases (RNRs), which catalyze the conversion of nucleotides to deoxynucleotides and play an essential role in DNA replication and repair. Stubbe supports a range of ongoing projects, including those related to the radical propagation pathway utilized by Class I RNRs, the interactions between protein subunits of Class I RNR, the regulation of RNRs, and the mechanisms behind clinical drugs. She also examines the biosynthesis, activation, and regulation of formation of the essential metallo-cofactors of RNRs in E. coli, S. cerevisiae, and humans. JoAnne Stubbe is no longer accepting students.