Our X-ray Laboratory provides access to state-of-the-art equipment and technologies, hosts a crystallography course and X-ray diffraction application training, and offers advice and technical assistance in crystal growth, data collection, and structure refinement. We welcome all Harvard affiliates as well as external users. For more information, view our brochure.
Instrumentation & Services
Small Molecule Single Crystal Diffraction
The Advanced Photon Source (APS) Argonne National Lab regularly awards our Lab beam time for micro-crystallography studies, high resolution charge density studies, and resonant diffraction studies. Thanks to the tunable, high-intensity X-ray beams at ChemMatCARS, our X-ray laboratory has been using advanced crystallography as an essential research tool for:
- Routine service crystallography for micro-sized crystals (less than 10 micron in two dimensions) that cannot be measured elsewhere.
- Charge density work, including ultra-high resolution, ultra-low temperature data collection, multipole refinement, and charge density analysis combined with theoretical calculations.
- Photocrystallography in exploring molecular meta-stable states. The determination of molecular motions in the crystal is based on difference maps and disorder model refinements.
- Structural studies at different temperature: from ~10 K (Helium temperature) to 400 K.
- Resonant diffraction studies/Diffraction anomalous fine structure.
- Target guest structural determination by using crystalline sponge method.
X-ray Diffraction for Thin Film and Powder Samples